Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active.

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In this review, I summarize the various features of furin: its structural and enzymatic properties, autoactivation, intracellular localization and trafficking; its substrates; and its roles in vivo, including the requirement for furin in determining the pathogenicity of many viruses and bacteria. Box 1 The discovery of furin.

Mar 9, 2021 · Originally identified in 1990, furin is a cellular endoprotease that proteolytically activates many proprotein substrates ranging from pathogenic agents to growth factors, receptors, and...

Mar 30, 2025 · FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. Diseases associated with FURIN include Cerebral Amyloid Angiopathy, Itm2b-Related, 1 and Anthrax Disease. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and HIV Life Cycle.

In this review, we describe the physiological and pathophysiological substrates of furin and discuss how dysregulation of a simple proteolytic cleavage event may promote infectious diseases and cancer. One major focus is the role of furin in …

Furin (human) is a 794 residue Type I transmembrane protein with a large lumenal segment, including signal peptide, pro-, catalytic, P or “homoB,” and Cys-rich domains, a transmembrane domain, and a 56 aa cytoplasmic domain (see Fig. 1).

Furin, a calcium-dependent serine protease, belongs to a family of mammalian processing enzymes called proprotein convertases (PCs). 15,16 Up to seven members of this family have been identified to date.

Jul 14, 2024 · The furin enzyme is a member of the proprotein convertase family, characterized by its ability to cleave precursor proteins at specific sites. Structurally, furin is a type I transmembrane protein, meaning it spans the membrane of the Golgi apparatus, where it primarily resides.

May 23, 2023 · QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis