This paper addresses the diagnostic utility of FDG-PET over clinical/neuropsychological assessment in the differentiation of the three forms of primary progressive aphasia (PPA). Methods: Seven panelists were appointed by the EANM and EAN and a literature search was performed by using harmonized PICO (Population, Intervention, Comparison ...

Mar 1, 2002 · Myocardial ischemia is associated with reduced free fatty acid (FFA) β-oxidation and increased glucose utilization. This study evaluated the potential of dynamic SPECT imaging of a FFA analog, p - 123 I-iodophenylpentadecanoic acid (IPPA), for detection of ischemia and compares retention of IPPA with 18 F-FDG accumulation.

Aug 1, 2022 · Meta-analyses have shown disjunction between hypometabolism and atrophy in imaging studies on PPA, indicating the need for different diagnostic imaging criteria for 2-deoxy-2- [18F]fluoro-D-glucose (FDG) positron emission tomography (PET) and for …

FDG-PET shows distinct spatial metabolic patterns which can aid in distinguishing between various forms of dementia. A 2021 study conducted by Minoshima et al. demonstrated the ability to quantify disease progression in PPA by evaluating the atrophy rate using FDG-PET over time.

18 F-FDG PET detected focal cardiac uptake and multiple lymph node disease in the supraclavicular, mediastinum, hilum, abdominal, and pelvis region at pre-therapy. 18 F-FDG uptake is seen at the same site of LGE-MRI abnormal intensity. At post-therapy, 18 F-FDG uptakes were markedly lower.

log, p-123I-iodophenylpentadecanoic acid (IPPA), for detection of ischemia and compares retention of IPPA with 18F-FDG accumu-lation. Methods: In a canine model of regional low-flow ischemia (n 9), serial IPPA SPECT images (2 min per image) were acquired over 52–90 min. In a subset of dogs (n 6), 18F-FDG was injected

This study evaluated the potential of dynamic SPECT imaging of a FFA analog, p-(123)I-iodophenylpentadecanoic acid (IPPA), for detection of ischemia and compares retention of IPPA with (18)F-FDG accumulation.

Jul 19, 2024 · The three PPA subtypes show distinct regions of hypometabolism in FDG-PET imaging with SD in the anterior temporal lobes, LPA in the left temporo-parietal junction, and nonfluent/agrammatic Variant PPA (nfvPPA) in the left inferior frontal gyrus and insula.

In the brain, glucose metabolism provides approximately 95% of adenosine triphosphate (ATP) required for brain function.

Oct 6, 2005 · 10-12 F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and single-photon emission computed tomography (SPECT) assess glucose metabolism. 13-23 Free fatty acid metabolism can be evaluated with I-123 IPPA 24 and I-123 BMIPP.