Immunoreactivity for ezrin, a membrane-organizing phosphoprotein that tethers actin microfilaments to cell membrane proteins, was evaluated as a polarization marker in the intraocular neuroepithelial cells of vertebrates, especially in the retinal pigment epithelium (RPE).

Here, we demonstrate two specific morphogenetic roles of ezrin in the retinal pigment epithelium (RPE), i.e., the formation of very long apical microvilli and of elaborate basal infoldings typical of these cells, and characterize the role of ezrin in these processes using antisense and …

Feb 12, 2025 · We demonstrated recently that Ezrin is a key regulator of lysosomal biogenesis and functions in RPE/retina crosstalk by modulating TFEB nuclear translocation (Naso et al., 2020). Moreover, Ezrin overexpression leads to altered autophagy and an impairment of POS maturation and degradation in RPE cells (Naso et al., 2020).

Jul 8, 2021 · We propose that βA3/A1-crystallin acquired its RPE function before evolving as a structural element in the lens, and that in the RPE, it modulates the PI (4,5)P 2 pool through PITPβ/PLC...

Oct 7, 2024 · Deubiquitinated ENKD1 interacts with Ezrin, a membrane-cytoskeleton linker, and stimulates the microvillar localization of Ezrin, which is essential for the phagocytic activity of RPE cells.

Our results suggest that EZRIN/EGFR/TSC molecular network controls mTORC1 on lysosomes in the RPE. Depletion of Ezrin alters endosomal EGFR signaling thereby triggering defects in autophagy pathway and leading to retinal degeneration.

Apr 15, 2020 · Here, we show that the light-responsive miR-211 controls lysosomal biogenesis at the beginning of light-dark transitions in the RPE by targeting Ezrin, a cytoskeleton-associated protein essential for the regulation of calcium homeostasis. miR-211-mediated down-regulation of Ezrin leads to Ca 2+ influx resulting in the activation of calcineurin ...

RPE-ezrin-/- mice expressed low levels of several apical plasma membrane proteins including Glut-1, CRALBP, and peropsin. ERG studies of RPE-ezrin-/- mice noted only minor changes under dark- and light-adapted conditions; all RPE-driven …

We have previously shown that ezrin is expressed and plays an important role in establishing and maintaining apical microvilli of RPE and Müller cells, and RPE basal infoldings.

Immunoreactivity for ezrin, a membrane-organizing phosphoprotein that tethers actin microfilaments to cell membrane proteins, was evaluated as a polarization marker in the intraocular neuroepithelial cells of vertebrates, especially in the retinal pigment epithelium (RPE).