Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene. [5] [6] [7] [8]

Mar 30, 2025 · EIF2AK3 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3) is a Protein Coding gene. Diseases associated with EIF2AK3 include Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus and Menkes Disease. Among its related pathways are Signaling by ALK in cancer and Alzheimer's disease and miRNA effects.

Feb 8, 2025 · Eif2ak3 acts as a metabolic sensor in the insulin-secreting beta-cells to modulate the trafficking and quality control of proinsulin in the endoplasmic reticulum. PERK-dependent signaling is used during both tumor initiation and expansion to maintain redox homeostasis, thereby facilitating tumor growth.

PERK is a potential target for cancer therapy, specifically in the context of drug-resistant cancers. The endoplasmic reticulum (ER)-stress defence modulator PERK (eIF2AK3) is a direct downstream transcriptional target of FOXO3. Rare variants in EIF2AK3 may be associated with disease risk in AD.

Nov 27, 2024 · Title: Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV. DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.

Aug 3, 2022 · ER stress induces the unfolded protein response (UPR) in which EIF2AK3, encoding the protein kinase RNA-like ER kinase (PERK), acts as a key regulator.

Gross (2016) mapped the EIF2AK3 gene to chromosome 2p11.2 based on an alignment of the EIF2AK3 sequence (GenBank AF110146) with the genomic sequence (GRCh38). Malfolded proteins in the endoplasmic reticulum (ER) inhibit translation initiation.

EIF2AK3 - eukaryotic translation initiation factor 2 alpha kinase 3 Synonym(s): PEK, PERK, PKR-like ER kinase, PRKR-like endoplasmic reticulum kinase, pancreatic eIF-2alpha kinase Previous symbol(s) and name(s):

Population studies implicate EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3), better known as PERK (protein kinase R-like endoplasmic reticulum kinase), as a genetic risk factor in several tauopathies.

EIF2AK3 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.