Drosha is a Class 2 ribonuclease III enzyme [5] that in humans is encoded by the DROSHA (formerly RNASEN) gene. [6][7][8] It is the primary nuclease that executes the initiation step of …

Mar 30, 2025 · DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Pineoblastoma and Hereditary Breast Ovarian Cancer …

DROSHA is the catalytic subunit of the Microprocessor complex, which initiates microRNA (miRNA) maturation in the nucleus by recognizing and cleaving hairpin precursors embedded …

Drosha is the catalytic center of the microprocessor and has two RNase-III domains that make up a catalytic site with each domain making one of the two cuts necessary to excise the pre …

Apr 29, 2016 · A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and …

Jul 20, 2012 · DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of …

Jan 14, 2016 · The heretofore-elusive structure of DROSHA provides insights into how nascent microRNAs are recognized and cleaved in their initial processing step and reveals an …

Dec 12, 2013 · Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we …

Nov 25, 2021 · We recently discovered that a human RNase III, DROSHA, exhibits a single cleavage on the one strand of primary microRNAs (pri-miRNAs). This study revealed that …

Nov 24, 2014 · The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003). By database searching and …