Dec 17, 2015 · DYRK1A syndrome is characterized by intellectual disability including impaired speech development, autism spectrum disorder including anxious and/or stereotypic behavior problems, and microcephaly.

DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive- histidine repeat. It catalyzes its autophosphorylation on serine / threonine and tyrosine residues.

DYRK1A-related intellectual disability syndrome is a rare genetic condition. People with this syndrome often have a smaller head size (microcephaly), delayed development, mild to severe intellectual ability, difficulty with speech and feeding, and behavior problems.

Investigation of the genetic overdosage found in Down syndrome, due to the trisomy of human chromosome 21, has pointed to one main driver gene, the Dual-specificity tyrosine-regulated kinase 1A (Dyrk1a). Dyrk1a is a murine homolog of the drosophila minibrain gene.

Mar 8, 2025 · It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be …

DYRK1A has been identified as both an oncogene and tumor suppressor in different models, underscoring the importance of cellular context in its function. Here, we review mechanistic contributions of DYRK1A to cancer biology and its role as a potential therapeutic target.

DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural progenitors.

Dec 24, 2024 · DYRK1A (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A) is a Protein Coding gene. Diseases associated with DYRK1A include Intellectual Developmental Disorder, Autosomal Dominant 7 and Dyrk1a-Related Intellectual Disability Syndrome. Among its related pathways are Cell Cycle, Mitotic and Mitotic G1 phase and G1/S transition.

DYRK1A is another name for the dual specificity tyrosine phosphorylation regulated kinase 1A gene. It is located on chromosome 21 in the q22.13 region and provides instructions for making a kinase enzyme. The DYRK1A enzyme is important in the development of the nervous system. What is DYRK1A Syndrome?

Jun 1, 2023 · Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily conserved protein kinase and the most studied member of the Dual-specificity tyrosine-regulated kinase (DYRK) family.