Desmin is a 53.5 kD protein composed of 470 amino acids, encoded by the human DES gene located on the long arm of chromosome 2. [10][11] There are three major domains to the desmin protein: a conserved alpha helix rod, a variable non alpha helix head, and …

Nov 15, 2004 · Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles. Desmin filaments are mainly located at the periphery of Z-disk of striated muscles and at the dense bodies of smooth muscle cells, and they have been postulated to play a criti …

Desmin is a protein made by muscle cells. Non-cancerous and cancerous tumours made up of muscle cells also produce desmin.

Differentiates mammary type myofibroblastoma (desmin+) from spindle cell lipoma (16% desmin+), cellular angiofibroma (5% desmin+) and solitary fibrous tumor (desmin-)

The present review uses a bibliometric approach to assess the research on desmin, and to compare its alleged functions. Based on the interpretation of the comparative list of functions we organized, we propose a new approach to interpret the function of desmin.

Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force transmission, and mitochondrial homeostasis.

The DES gene provides instructions for making a protein called desmin. Desmin is found in heart (cardiac) muscle and muscles used for movement (skeletal muscle). Within muscle fibers, …

Desmin is a member of the large multigene family of IF proteins and is specifically expressed in myocytes. In an effort to elucidate its muscle-specific behavior, we have used a yeast two-hybrid system in order to identify desmin’s head binding partners.

We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator. Expression of p.R406W mutant desmin, identified in patients with desmin-related myopathy, modified focal adhesion area and expression of adhesion-signaling genes in …

Oct 31, 2014 · Desmin is a muscle-specific type III intermediate filament essential for proper muscular structure and function. In human, mutations affecting desmin expression or promoting its aggregation lead to skeletal (desmin-related myopathies), or cardiac (desmin-related cardiomyopathy) phenotypes, or both.