The first demonstration of retrograde eCB signaling came from the discovery that eCBs mediate forms of short-term synaptic plasticity known as depolarization-induced suppression of inhibition (DSI) (Ohno-Shosaku et al., 2001; Wilson and Nicoll, 2001) and depolarization-induced suppression of excitation (DSE) (Kreitzer and Regehr, 2001).

Feb 29, 2024 · In vitro studies have shown that robust postsynaptic calcium (post-Ca) increase during DSI triggers eCB synthesis and the retrograde activation of cannabinoid type-1 receptors (CB 1 s), which in turn suppresses GABA release.

May 29, 2023 · Together, the impaired eCB-LTD and DSI results mirror the Syn-tKO phenotypes and suggest that postsynaptic SNAREs are required for eCB-dependent plasticity.

The endocannabinoid (eCB) signaling system plays a key role in short-term and long-term synaptic plasticity in brain regions involved in various neural functions ranging from action selection to appetite control. This review will explore the role of ...

CB1Rs also mediate short-term plasticity exemplified by Depolarization-induced Suppression of Inhibition or Excitation (DSI or DSE, respectively). DSI/DSE is well characterized in the hippocampus and cerebellum, and has been observed in other brain areas (2, 5).

Sep 15, 2017 · The dorsal striatum (DS) of the basal ganglia plays a critical role in voluntary movement, learning and motivation, and represents the primary site of dysfunction in psychomotor diseases. The DS integrates glutamatergic excitatory inputs from the cortex and the thalamus.

Thus the lack of DSI in INs does not appear to be due to an insufficient increase in intracellular calcium or enhanced reuptake. These results suggest that layer 2/3 INs receive CB1-expressing inhibitory inputs, but that eCBs are not released by these INs.

Endocannabinoid (eCB)–mediated suppression of inhibitory synapses has been hypothesized, but this has not yet been demonstrated to occur in vivo because of the difficulty in tracking eCB dynamics and synaptic plasticity during behavior.

Sep 29, 2009 · Depolarization-induced suppression of excitation and inhibition (DSE/DSI) appears to be an important form of short-term retrograde neuronal plasticity involving endocannabinoids (eCBs), the activation of presynaptic cannabinoid CB1 receptors, and the suppression of neurotransmitter release.

Jun 7, 2007 · Unlike manipulations involving the CB1 receptor, the RIM1α KO maintains short term eCB mediated plasticity (DSI) without the long term form (I-LTD). These mice have striking deficits in acquiring both hippocampus- and amygdala-dependent memories ( Powell …