Function and biological roles of the Dickkopf family of Wnt
Dec 4, 2006 · Dkks play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero–posterior axial patterning, limb development, …
Dickkopf Proteins and Their Role in Cancer: A Family of Wnt …
The ability of DKK proteins to inhibit the Wnt pathway suggests a function for them as possible tumor suppressor genes owing to the most preponderant pro-oncogenic role of overactivation …
DKK1, a negative regulator of Wnt signaling, is a target of the
Sep 20, 2004 · Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of …
The Clinical Significance of Dickkopf Wnt Signaling Pathway …
Dickkopf Wnt signaling pathway inhibitor (DKK) gene family, which is known to inhibit the Wnt regulation process, is widely found in cancers. However, the roles and functions of specific …
Function and biological roles of the Dickkopf family of Wnt
Dec 4, 2006 · Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted …
Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk
Dickkopf (Dkk) proteins are antagonists of the canonical Wnt signaling pathway and are crucial for embryonic cell fate and bone formation. Wnt antagonism of Dkk requires the binding of the C …
Wnt signaling in cancer: from biomarkers to targeted therapies …
Apr 2, 2025 · By disrupting Wnt signaling, Dkk-1 blocks β-catenin stabilization and nuclear translocation . Beyond its role as a Wnt pathway antagonist [183, 184], Dkk-1 has garnered …
DKK1 - Wikipedia
It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 …
Dkk (Dickkopf) Proteins | Arteriosclerosis, Thrombosis, and …
May 16, 2019 · Dkk (Dickkopf) family proteins are important regulators of the Wnt/β-catenin signaling pathway, which plays key roles in many essential biological processes and in a …
Dickkopf | The Wnt Homepage - Stanford University
Jan 1, 2025 · Dickkopf (Dkk) is a negative regulator of Wnt signaling (Glinka, 1998; Niehrs, 1999) The Dkk protein is secreted and rich in cysteines. Dkk does not bind to Wnt but interacts with …