Contributions made by the dystrophin-associated glycoprotein complex (DGC) to cell-cell and cell-extracellular matrix (ECM) interactions are vital in development, homeostasis and pathobiology. This review explores how DGC functions may extend to skeletal pathophysiology by appraising the known roles …

Mar 12, 2025 · Among these, the dystrophin glycoprotein complex (DGC) plays a crucial role in maintaining muscle stability and protecting fibers from damage during contraction. Disruptions in this complex are linked to severe neuromuscular disorders, making its study essential for understanding muscle diseases.

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The dystrophin glycoprotein complex (DGC) has a crucial role in maintaining cell membrane stability and integrity by connecting the intracellular cytoskeleton with the surrounding extracellular matrix 1-3.

The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically remodels during cardiac disease. This review examines DGC remodeling as a common denominator in diseases affecting heart function and health.

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In this study, we focused on the acute effects of FHL2 expression on early DGC development, however, there may be differential effects of chronic upregulation and blockade of FHL2 expression on dendritic growth in the adult brain, which will require further exploration.

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