DFX117 is a selective, orally active inhibitor for PI3Kα and c-Met tyrosine kinase. DFX117 inhibits PI3K/Akt/mTOR pathway, inhibits the proliferation of NCI-H1975, NCI-H1993, and HCC827 …

(A) The proliferation of four lung cancer cell lines (A549, NCI-H1975, PC9 and NCI-H1993) were significantly inhibited by DFX117. (B) DFX117 showed few effects on cell growth of normal cell …

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May 5, 2019 · Concurrent targeted c-Met and PI3Kα by DFX117 dose-dependent inhibited the cell growth of H1975 cells (PIK3CA mutation and c-Met amplification) and A549 cells (KRAS …

DFX117 Cat. No.: HY-164384 CAS No.: 2125500-60-7 Molecular Formula: C26H26F2N6O5S Molecular Weight: 572.58 Target: PI3K; Akt; mTOR; Apoptosis Pathway: PI3K/Akt/mTOR ...

DFX-117|DFX 117: Drug Descriptions: DFX117 is a dual inhibitor that blocks Met and selectively inhibits Pik3ca kinase activity, which potentially results in inhibition of cell proliferation, and …

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Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4α in Colorectal Cancer Cells