Chemokine (C-X-C motif) ligand 17 (CXCL17) is a small cytokine belonging to the CXC chemokine family that has been identified in humans and mice. CXCL17 attracts dendritic cells and monocytes and is regulated in tumors.

Mar 30, 2025 · CXCL17 (C-X-C Motif Chemokine Ligand 17) is a Protein Coding gene. Diseases associated with CXCL17 include Cholera. Among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and …

May 29, 2024 · CXCL17, a novel member of the CXC chemokine class, has been implicated in several human pathologies, but its role in mediating immune response is not well understood. Characteristic features of immune response include resident macrophages orchestrating successive and structured recruitment of neutro …

CXCL17 has been classified as a CXC-type chemokine in two independent research articles (5, 6). In the former (6) the claim is based on the observation that “the human [CXCL17] sequence … contains six cysteine residues, with four of them occurring in two CXC motifs”.

Jan 1, 2013 · CXCL17 is an orphan chemokine preliminarily found to be involved in tumor angiogenesis. However, its protein nature, as well as its endogenous bioactivity, has not been well clarified.

Feb 8, 2025 · CXCL17 increases MDSCs PDGF-BB secretion which contributes to MDSC-mediated angiogenesis in the lung metastatic niche and colonization of breast cancer. Patients with high levels of CXCL17 have shorter distant metastasis-free and overall survival rates.

Jun 1, 2020 · CXCL17, a myeloid cell-attracting chemokine, also known as dendritic cell and monocyte-like protein (DMC) or VEGF co-regulated chemokine 1 (VCC-1), is the newest member of the CXCL family of chemotactic cytokines described so far [18].

Mar 19, 2024 · CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial properties. CXCL17 is also implicated in the pathology of inflammatory disorders and progression of several cancers, and its expression is increased during viral infections of the lung.

Jul 1, 2023 · CXCL17 can be produced by airway epithelium, playing positive and pathological role respectively in different cancers. It is chemoattractant of monocytes and macrophages.

Sep 1, 2020 · CXCL17, the last described chemokine, has recently been found to be abundantly and specifically expressed in mucosal sites, while its receptor is still not well determined. Accumulative studies indicate that CXCL17 could potentially exhibit chemotactic, anti-inflammatory, antimicrobial activities under multiple biological conditions.