It is a positive -strand DNA virus with single-stranded DNA (ssDNA). CTXφ infects some strains of Vibrio cholerae, the bacterium that causes cholera. It carries the genes for cholera toxin (CTX), which makes cholera especially virulent. It can carry …

Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of V. cholerae, the study of the lysogenic phage CTXΦ has attracted much attention.

The genes encoding cholera toxin, one of the principal virulence factors of the diarrhoeal pathogen Vibrio cholerae, are part of the genome of CTXphi, a filamentous bacteriophage. Thus, CTXphi has played a critical role in the evolution of the pathogenicity of V. cholerae.

CTXphi is a filamentous phage that encodes cholera toxin, one of the principal virulence factors of Vibrio cholerae. CTXphi is unusual among filamentous phages because it can either replicate as a plasmid or integrate into the V. cholerae chromosome at a specific site.

CTXphi is a lysogenic, filamentous bacteriophage. Its genome includes the genes encoding cholera toxin (ctxAB), one of the principal virulence factors of Vibrio cholerae; consequently, nonpathogenic strains of V. cholerae can be converted into toxigenic strains by CTXphi infection.

Mar 2, 2010 · CTXϕ is a small, positive, single-stranded DNA [(+) ssDNA)] virus that can be found either in a replicative form or, more commonly, integrated site-specifically in the host genome to form stable lysogens.

Vibrio phage CTXphi carries three genes for toxin production: ace (accessory cholera enterotoxin) which is a minor coat protein, zot (zonula occludens toxin) responsible for maturation and ctxAB without a known function in the phage replication cycle, but whose product is the cholera A-B enterotoxin (CT).

Sep 24, 2024 · CTXΦ is a lysogenic filamentous phage that carries the genes encoding cholera toxin (ctxAB), the main virulence factor of Vibrio cholerae. The toxigenic conversion of environmental V. cholerae strains through CTXΦ lysogenic infection is crucial for the emergence of new pathogenic clones.

Feb 29, 2020 · CTXϕ exploits two host-encoded tyrosine recombinases, XerC and XerD, for its integration in the highly conserved dimer resolution site (dif) of V. cholerae chromosomes. CTXϕ can replicate only in the limited number of Vibrio species.

Vibrio phage CTX, complete genome. CTX prophages in Vibrio cholerae O1 strains. J Microbiol Biotechnol. 2014 Jun 28;24 (6):725-31.