Human COPB2 genome location and COPB2 gene details page in the UCSC Genome Browser. Overview of all the structural information available in the PDB for UniProt: O55029 (Mouse Coatomer subunit beta') at the PDBe-KB.

Mar 28, 2025 · COPB2 (COPI Coat Complex Subunit Beta 2) is a Protein Coding gene. Diseases associated with COPB2 include Microcephaly 19, Primary, Autosomal Recessive and Osteoporosis, Childhood- Or Juvenile-Onset, With Developmental Delay.

In this paper, we focus on the emerging roles of COPB2 in cancer development and progression in the context of the hallmarks of cancer. Through this comprehensive review, we discuss the accumulating evidence for the future clinical utilization of COPB2 as a …

May 24, 2022 · The COPB2 gene encodes a subunit of the Golgi coatomer complex (see 601924), which is necessary for retrograde trafficking from the Golgi to the endoplasmic reticulum.

COPB2 significantly promoted PC-3 cell proliferation and colony formation through the cell cycle and apoptosis pathway. COPB2 showed a clinical correlation and may serve as a biomarker for the detection for prostate cancer.

The Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum.

Based on the present findings, we hypothesize that COPB2 is essential for the proliferation of colon cancer cells, and that lentivirus-mediated COPB2 silencing may be a promising therapeutic method for the treatment of colon cancer.

Silencing of COPB2 inhibited the proliferation, migration, and invasion abilities by suppressing epithelial-mesenchymal transition and mTOR signaling. COPB2 is a novel prognostic biomarker and a promising therapeutic target for HCC. 1. Introduction.

Sep 2, 2021 · We have identified loss-of-function variants in COPB2, a component of the coatomer complex I (COPI), in individuals presenting with osteoporosis, fractures, and developmental delay of variable severity.

Jun 8, 2021 · COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the current knowledge on the roles of COPB2 in cancer development and progression in the context of the hallmarks of cancer.