ADF/cofilin is a family of actin-binding proteins associated with the rapid depolymerization of actin microfilaments that give actin its characteristic dynamic instability. [1] This dynamic instability …

Oct 12, 2021 · Cofilin modulates actin transport and function in the nucleus as well as actin organization associated with mitochondrial fission and mitophagy. Under neuronal stress …

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent …

Cofilin is best known as a regulator of actin filament non-equilibrium assembly/disassembly . Whether cofilin promotes actin assembly or disassembly depends upon the concentration of …

May 5, 2017 · Cofilins are evolutionary conserved proteins present in all Eukaryotic cells. Their primary function is dynamic reorganization of actin cytoskeleton. Two cofilin isoforms are …

Mar 5, 2002 · The ADF/cofilins are a family of actin-binding proteins that remodel the actin cytoskeleton, for example during cytokinesis, by severing actin filaments and also increasing …

Jun 19, 2013 · The combination of structural data for filament severing with recently discovered mechanisms for cofilin activation in migrating cells is increasing our understanding of how …

Cofilin is an actin-binding protein that depolymerizes and/or severs actin filaments. This dual function of cofilin makes it one of the major regulators of actin dynamics important for T-cell …

Sep 1, 2016 · Cofilin clusters PIP 2 molecules at the membrane through its interaction with multiple PIP 2 headgroups; hence, changes in PIP 2 density can effectively regulate cofilin …

Apr 8, 2008 · What are ADF and cofilin and how do they differ structurally? The first member of this family, actin-depolymerizing factor (ADF), was isolated in 1980 from embryonic chick brain …