Mar 8, 2012 · Here we assessed the ability of CLEC9A to mediate antigen presentation by human BDCA3 + mDCs, which represent < 0.05% of peripheral blood leukocytes. We demonstrate that CLEC9A is only expressed on immature BDCA3 + mDCs and that cell surface expression is lost after TLR-mediated maturation.

Feb 7, 2025 · Through activation of the immunoreceptor tyrosine-based activation motif (ITAM)-spleen tyrosine kinase (Syk) signaling pathway, Clec9a promotes downstream immune responses that drive robust ...

Jun 13, 2008 · CLEC9A possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase, and we demonstrate, using receptor chimeras, that this receptor can induce proinflammatory cytokine production. These data indicate that CLEC9A functions as an activation receptor.

Many mammalian immunoreceptors signal through cytoplasmic tyrosine-based sequence motifs. One of the most well characterized motifs is the immunoreceptor tyrosine-based activation motif (ITAM), which contains two tyrosine core modules in tandem orientation.

Jun 13, 2016 · The stalk region of CLEC9A possesses two cysteines, potentially involved in receptor dimerization, and a single predicated N -linked glycosylation site. The cytoplasmic tail contains a single tyrosine residue within a sequence showing similarity to the ITAM-like sequence of Dectin-1 (18).

CLEC9A, via Hemi-ITAM (HITAM) plays a key role in CD8 + T cell cross-priming. In addition, CLEC9A can activate SHP-1 to exert inhibitory feedback and restrain excessive immune response.

Through activation of the immunoreceptor tyrosine-based acti-vation motif (ITAM)-spleen tyrosine kinase (Syk) signaling pathway, Clec9a promotes downstream immune responses that drive robust...

Oct 31, 2024 · CLEC9A recognition of cell death in a mouse model of acute pancreatitis or after systemic C. albicans infection inhibited the production of the neutrophil-recruiting chemokine MIP-2 by cDC1s, reducing neutrophil recruitment and promoting disease tolerance (del Fresno et …

Jan 16, 2012 · The cytoplasmic tail of Dectin-1, CLEC-2, CLEC9A and LOX1 contains immunoreceptor tyrosine-based activation motif (ITAMs) (Figure 1), and ligation of these receptors results in the induction...

Through activation of the immunoreceptor tyrosine-based activation motif (ITAM)-spleen tyrosine kinase (Syk) signaling pathway, Clec9a promotes downstream immune responses that drive robust antitumor immunity.