Dec 15, 2022 · Here, we outline the current conception of immune response and the regulation mechanism of cGAS in the nucleus. Furthermore, we will shed light on the potential mechanisms that are restricted to be taken away from self-DNA recognition, especially how post-translational modification regulates cGAS functions.

Sep 10, 2020 · Here we show that cGAS binds to nucleosomes with nanomolar affinity and that nucleosome binding potently inhibits its catalytic activity.

Based on the current understanding of the structure, subcellular localization and canonical functions of cGAS, this review focuses on summarizing the mechanisms underlying nucleo-cytoplasmic transport, activity regulation and non-canonical functions of cGAS in the nucleus.

This review explores the latest advances in nuclear cGAS, including proposed models for its nuclear localization, mechanisms governing nuclear cGAS silencing and activation, and the biological significance of its presence in the nucleus.

Mar 7, 2024 · Based on the current understanding of the structure, subcellular localization and canonical functions of cGAS, this review focuses on summarizing the mechanisms underlying nucleo-cytoplasmic transport, activity regulation and …

Feb 28, 2024 · Here we show that the ubiquitin proteasomal system (UPS) degrades nuclear cGAS in cycling cells. We identify SPSB3 as the cGAS-targeting substrate receptor that associates with the cullin–RING...

Mar 21, 2024 · In contrast with typical nuclear/cytosolic distribution mechanisms — which rely on selective transport through the nuclear pore complex — cGAS is slowly eliminated by ubiquitin-mediated...

Jul 12, 2021 · Cryo‐EM structures have revealed that cGAS interacts with nucleosomes, the minimal units of chromatin, mainly via histones H2A/H2B, and that these protein–protein interactions block cGAS from DNA binding and thus prevent autoreactivity.

Does cGAS activate the immune response in the nucleus, because cGAS was found as a chromatin-bound protein in the nucleus, and what mechanism restricts the recognition of cGAS to host genome DNA?

5 days ago · Context-dependently, cGAS resides in diverse cellular compartments, including the nucleus, micronuclei, plasma membrane, and organelle surfaces. Beyond its DNA-sensing role, cGAS can play complex roles in these locations, such as DNA damage repairing, membrane restoration, chromatin condensation, angiogenesis, and aging regulation.