CFPAC-1 cells show no effect of cAMP agonists, adenyl cyclase stimulators or phosphodiesterase inhibitors on Cl- flux, but do respond to Ca++ ionophores with increase Cl- efflux. The cells have the most common form of the CF mutation, deletion of three nucleotides resulting in the absence of phenylalanine at position 508.

Genome-wide array-based comparative genomic hybridization reveals multiple amplification targets and novel homozygous deletions in pancreatic carcinoma cell lines. Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.

It is likely that the CFPAC-1 pancreas cancer cell line may have resulted from unique molecular events that may not be representative of the basic pathogenesis which characterizes the majority of pancreas cancer cases.

Jan 5, 2022 · Cell information for CFPAC-1. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

We established a pancreatic adenocarcinoma cell line (CFPAC-1) from a patient with cystic fibrosis (CF) and assessed some of its properties. The cells show epithelial morphology and express cytokeratin and oncofetal antigens characteristic of pancreatic duct cells.

CFPAC-1 is a ductal pancreatic adenocarcinoma derived by differential trypsinisation of explant cultures from a metastatic lesion in the liver of a 26 year old caucasian male with cystic fibrosis (CF).

CFPAC-1 cells, derived from a 26-year-old male with cystic fibrosis and liver metastasis of ductal adenocarcinoma, are a hyperdiploid cell line with notable features for biological research. Their adherence growth property and tumorigenic capability in nude mice make them a practical model for in vitro cancer studies.

Apr 8, 2021 · CFPAC-1 cells were used as the positive control and HPNE cells as the negative control. Cell populations with high mutant frequencies were selected and seeded in 96-well plates with limiting...

CFPAC-1 is a ductal pancreatic adenocarcinoma derived by differential trypsinisation of explant cultures from a metastatic lesion in the liver of a 26 year old caucasian male with cystic fibrosis (CF).

Oct 5, 2023 · CFPAC-1/Cas9-hyg: Accession: CVCL_C9DR: Resource Identification Initiative: To cite this cell line use: CFPAC-1/Cas9-hyg (RRID:CVCL_C9DR) Comments: Population: Caucasian. Characteristics: Stably expresses a EF1a-Cas9-HA-SV40-EGFP-IRES-HygR construct (GeneCopoeia=SL540). Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note ...