Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene. [5] [6] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication.

Mar 28, 2025 · CDC6 (Cell Division Cycle 6) is a Protein Coding gene. Diseases associated with CDC6 include Meier-Gorlin Syndrome 5 and Meier-Gorlin Syndrome 1. Among its related pathways are Activation of the pre-replicative complex and CDK-mediated phosphorylation and removal of Cdc6.

Nov 28, 2007 · Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. Its best-characterized function is the assembly of prereplicative complexes at origins of replication during the G 1 phase of the cell division cycle.

The CDC6 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). Learn about this gene and related health conditions.

Jun 23, 2021 · Here we report the cryo-EM structure at 3.3 Å resolution of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA. The structure reveals that Cdc6 contributes to origin DNA recognition via its...

In this review, we summarise the evidence for the role of Cdc6 overexpression in cancer, specifically that of pancreatic cancer. More importantly, we recapitulate the role of Cdc6 as part of the DNA damage response and on senescence—an important antitumour barrier—in the context of pancreatic cancer.

Jan 4, 2025 · CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma. FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6. The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.

Feb 8, 2025 · Title: CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma. FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.

The results indicate that CDC6 is indispensable for maintaining G2 arrest of meiosis and functions in G2/M checkpoint regulation in mouse oocytes. Moreover, CDC6 is also a key player regulating meiotic spindle assembly and metaphase-to-anaphase transition in meiotic oocytes.

In this study, we have investigated the ability of purified human Cdc6 (HsCdc6), expressed in the baculovirus system as a GST-tagged recombinant protein, to bind and hydrolyze ATP. We show that HsCdc6 bound specifically to ATP and displayed ATPase activity.