Calcium/calmodulin-dependent protein kinase type II beta chain is an enzyme that in humans is encoded by the CAMK2B gene. The enzyme belongs to the serine/threonine protein kinase family and to the Ca 2+ /calmodulin-dependent protein kinase subfamily. Calcium signalling is crucial for several aspects of plasticity at glutamatergic synapses.

Mar 30, 2025 · CAMK2B (Calcium/Calmodulin Dependent Protein Kinase II Beta) is a Protein Coding gene. Diseases associated with CAMK2B include Intellectual Developmental Disorder, Autosomal Dominant 54 and Autosomal Dominant Non-Syndromic Intellectual Disability .

The CAMK2B gene encodes the β-subunit of calcium/calmodulin-dependent protein kinase II (CAMK2), an enzyme that has crucial roles in synaptic plasticity, especially in hippocampal and cerebellar neurons.

Herein, after highlighting the main structural and expression differences between the α and β isoforms, we will review the specific functions of CaMKIIβ, as described so far, in neuronal development and plasticity, as well as its potential implication in brain diseases.

Feb 8, 2025 · CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF. The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.

CaMK2B has an autophosphorylation site at Thr287. It functions as a targeting or docking module. Reverse transcription-polymerase chain reaction and sequencing analysis identified at least five alternative splicing variants of beta CaMKII (beta, beta6, betae, beta'e, and beta7) in brain and two of them (beta6 and beta7) were first detected in ...

Sep 2, 2022 · Calcium–calmodulin (CaM)-dependent protein kinase II (CaMKII) is the most abundant protein in excitatory synapses and is central to synaptic plasticity, learning and memory. It is...

Jun 1, 2021 · CAMK2 is encoded by four distinct genes, known as CAMK2A, CAMK2B, CAMK2D and CAMK2G (Sloutsky et al., 2020; Tombes et al., 2003). Each CAMK2 subunit is composed of an N-terminal catalytic domain, a C-terminal hub domain and an autoregulatory domain in …

Jul 10, 2019 · Ca 2+ /calmodulin-dependent protein kinase II (CAMK2) is a key player in synaptic plasticity and memory formation. Mutations in Camk2a or Camk2b cause intellectual disability in humans, and severe plasticity and learning deficits in …

Jan 29, 2018 · The effect of CAMK2A and CAMK2B variants on CaMKII structure and firing of neurons was evaluated by computational structural analysis, immunoblotting, and electrophysiological analysis. Results: We identified a total of five de novo CAMK2A and CAMK2B variants in three and two individuals, respectively.