Cytochrome P450 2A13 is a protein that in humans is encoded by the CYP2A13 gene. [5] [6] [7] This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein ...

Mar 30, 2025 · CYP2A13 (Cytochrome P450 Family 2 Subfamily A Member 13) is a Protein Coding gene. Diseases associated with CYP2A13 include Acetaminophen Metabolism and Lung Cancer. Among its related pathways are Oxidation by cytochrome P450 and Metapathway biotransformation Phase I and II.

In the present study, we found that the transcriptional regulation of human CYP2A13 gene involves CCAAT/enhancer binding protein (C/EBP) transcription factors instead of NFI. DNase I footprinting and gel-shift assays with human lung nuclear extract identified two DNA elements bound by C/EBP.

CYP2A13 is the most efficient enzyme to metabolize N'-Nitrosonornicotine in vitro. CYP2A13 levels in human lungs can be suppressed by disease-associated inflammation in tissue donors. The transgenic CYP2A13 is active. CYP2A13 played a …

The reduction in lung adenocarcinoma has been associated with CYP2A13*2 genetic polymorphism given by C→T transition, leading to Arg257Cys substitution and reduced activity of CYP2A13 towards NNK. A stratification analysis demonstrated that the reduced risk of lung adenocarcinoma was related to the CYP2A13 variant and was limited to smokers ...

Jun 17, 2024 · Title: Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants. CYP2A13 is the most efficient enzyme to metabolize N'-Nitrosonornicotine in vitro.

May 12, 2006 · Human cytochrome P450 2A13 (CYP2A13) is highly efficient in the metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and another potent carcinogen, aflatoxin B1 (AFB1).

Nov 14, 2024 · Clinical resource with information about CYP2A13, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

CYP2A13 is the most efficient cytochrome P450 enzyme in the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. The aims of this study were to determine the levels of CYP2A13 protein in human lung microsomes and to ascertain whether CYP2A …

Mar 20, 2009 · RT-PCR detected highest CYP2A13 expression in nasal mucosa, followed by lung and trachea. Lower expression was detected in testis and liver, and weak expression was detected in brain, mammary gland, prostate, and uterus, but not in other tissues examined.