Nov 30, 2022 · CRISPR-Cas9-mediated TP53 and CDKN2A knockout (TP53/CDKN2AKO) in GEJ organoids induced morphologic dysplasia and proneoplastic features in vitro and tumor formation in vivo. Lipidomic profiling identified several platelet-activating factors (PTAFs) among the most up-regulated lipids in CRISPR-edited organoids.

In addition to mutations in the p53 tumor suppressor gene, genetic alterations in CDKN2A gene leading to loss of expression of p16 Ink4a and p14 ARF proteins may also play an important role in the development of human NMSC.

Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2A are associated with familial melanoma, glioblastoma and pancreatic cancer. [8]

May 2, 2022 · Results: Data analysis established the TP53 and CDKN2A mutation profiles in specific anatomic subsites and suggested that specific categories of TP53 mutations are more likely to associate with CDKN2A mutation or high TMB based on tumor subsite.

The accumulation of major driver alterations in pancreatic cancer, including CDKN2A, KRAS, p53 and SMAD4, is inversely associated with disease-free survival (DFS) and overall survival (OS), indicating a higher mortality risk with an increasing number of altered genes.

Lung squamous cell carcinoma (LUSC) is characterized by frequent mutations of tumor protein p53 (TP53) and cyclin dependent kinase inhibitor 2A (CDKN2A). However, to date, the impact of TP53/CDKN2A status on the clinical outcome of patients with early-stage LUSC is unclear.

Aug 22, 2019 · To this end, we have developed a bicistronic adenoviral vector encoding both the CDKN2A and p53 tumor suppressor genes. The bicistronic vector, AdCDKN2A-I-p53, supports the translation of...

p53 tumor suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Inactivation of CDKN2A can lead to deregulation of these two pathways.

May 2, 2022 · To gain insight into the relation of the interaction of TP53 and CDKN2A mutations with TMB in HNSCC, we have analyzed genomic data from 1,669 HPV-negative HNSCC tumors with multiple criteria proposed for assessing the damaging effect of TP53 mutations.

Jun 2, 2022 · Given the role of p14 ARF in regulating the MDM2-p53 pathway, we investigated the use of CDKN2A loss in the context of WT TP53 as a strategy for selection of patients who might benefit from milademetan.