Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. [5] It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations in the body.

Endoglin (CD105) is an accessory receptor for transforming growth factor beta (TGF-β) and its expression is up-regulated in actively proliferating endothelial cells. Endoglin has been suggested as an appropriate marker for tumor-related angiogenesis …

Surface expression of CD105 on human CD34 + cells. After purification from G-CSF mobilized peripheral blood using CD34 MACS beads, CD34 + cells were analyzed by flow cytometry for their CD105 surface expression either immediately or after stimulation for 24 h with Flt-3 ligand, stem cell factor, IL-3, IL-6, and TPO. (A) Representative FACS plots of CD34 + /CD105 + cells before and after ...

Antigens, CD ENG protein, human Endoglin Receptors, Cell Surface Transforming Growth Factor beta

Antigens, CD ENG protein, human Endoglin Receptors, Cell Surface Vascular Cell Adhesion Molecule-1

Jun 11, 2004 · Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in human cancer; however, a specific cell membrane marker for endothelial cells of tumor vasculature has not been discovered yet. Endoglin (CD105) is a cell-surface glycoprotein most recently identified as an optimal indicator of proliferation of human endothelial cells. The finding that CD105 is over ...

Oct 3, 2003 · Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly ...

Mar 18, 2025 · CD105, also known as endoglin, is a membrane glycoprotein primarily found on endothelial cells. It plays a crucial role in blood vessel formation and remodeling, making it significant in both normal physiology and disease.

Apr 1, 2008 · Endoglin was assigned the cluster of differentiation number 105 at the Fifth International Workshop on Human Leukocyte Differentiation Antigens and thus is also known as CD105 .

In this study CD 105 antibody was applied to the tissue sections employing immunohistochemistry. One section from each block, of 3-4 µm thickness was taken on Super-frosted slides after coating them with Poly-L-lysine.