BRCA Gene Changes: Cancer Risk and Genetic Testing
A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.
BRCA1 and BRCA2 (PDQ®) - NCI - National Cancer Institute
Evidence-based, expert-reviewed summary about the BRCA1 and BRCA2 genes and hereditary breast and ovarian cancer. This summary also contains information about the cancer risks associated with BRCA1/BRCA2, screening, risk-reduction, treatment, and prognosis.
Hoja informativa sobre los cambios en el gen BRCA y las pruebas …
En Esta Página ¿Qué son el BRCA1 y el BRCA2? ¿Cuánto aumenta el riesgo de cáncer de mama o cáncer de ovario si hay un cambio dañino hereditario en BRCA1 o en BRCA2? ¿Qué otros cánceres se relacionan con los cambios dañinos hereditarios en BRCA1 y en BRCA2?
Definición de gen BRCA2 - Diccionario de cáncer del NCI
Gen que da origen a una proteína que repara el ADN dañado. Las mutaciones (cambios) en el gen BRCA2 aumentan mucho el riesgo de presentar cáncer de mama y cáncer de ovario. También aumentan el riesgo de presentar otros tipos de cáncer, como el …
MRI, Surgery Reduce Cancer Deaths in Women with BRCA Changes
Apr 15, 2024 · For women in whom gene testing finds “harmful changes” in the BRCA1 or BRCA2 genes, leading medical groups recommend that they take specific actions to lower their chances of being diagnosed with or dying from breast and ovarian cancer.
Researchers categorize thousands of BRCA2 mutations as …
Feb 14, 2025 · A team of researchers led by Shyam K. Sharan, Ph.D., Senior Investigator in the Mouse Cancer Genetics Program, has categorized over 6,500 possible single nucleotide …
PALB2 and Associated Cancer Risks (PDQ®) - NCI
Feb 14, 2025 · However, individuals with PALB2 and BRCA2 pathogenic variants have higher rates of triple-negative breast cancer. PALB2 pathogenic variants are also associated with increased risks of contralateral breast cancer and male breast cancer.
Olaparib Approved for Breast Cancers with BRCA Gene Mutations
Jan 29, 2018 · The Food and Drug Administration has approved olaparib (Lynparza®) to treat metastatic breast cancers that have inherited mutations in the BRCA1 or BRCA2 genes as well as a companion diagnostic test for selecting candidates for the therapy.
Discovery – BRCA Connection to Breast and Ovarian Cancer
NCI-funded research helped identify inherited BRCA1 and BRCA2 genetic mutations and their connection to breast and ovarian cancer. From this research, a screening test was also developed to help patients make informed decisions about their health.
Surgery to Reduce the Risk of Breast Cancer Fact Sheet
Jan 31, 2025 · Bilateral mastectomy has been shown to reduce the risk of breast cancer by at least 95% in women who have a harmful (disease-causing) variant in the BRCA1 gene or the BRCA2 gene and up to 90% in women who have a strong family history of breast cancer (6 – 9).