The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome.

Mar 30, 2025 · Complete information for BCR gene (Protein Coding), BCR Activator Of RhoGEF And GTPase, including: function, proteins, disorders, pathways, orthologs, and expression.

The BCR gene provides instructions for making a protein whose function is not completely understood. Studies show that the BCR protein may act as a GTPase activating protein (GAP). GAPs turn off (inactivate) proteins called GTPases, which play an important role in chemical signaling within cells.

This review explores the mechanisms behind cancer progression of these BCR oncogenic fusion proteins, comparing their similarities and differences, examining the significance of BCR as a partner gene, and discussing current treatment options for these translocation-induced hematopoietic malignancies.

Apr 7, 2025 · The BCR-ABL fusion protein is a critical factor in the development of chronic myeloid leukemia (CML), a type of blood cancer. It is formed when a specific genetic mutation occurs, resulting in the abnormal combination of two genes, BCR (breakpoint cluster region) and ABL (abelson murine leukemia viral oncogene homolog). This mutation leads to the uncontrolled growth and proliferation of white ...

Bcr-abl regulates number of biological processes such as cell propagation, cell survival and cell trafficking. Importantly, overexpression of Bcr-abl induces chemo-resistance in CML [174]. Thus BCR-abl could be an essential therapeutic target in AML, ALL, and CML treatment [174].

Feb 8, 2025 · The ABL gene was inserted into the BCR region of chromosome 22 in chronic myelogenous leukemia. The molecular breakpoint of the BCR-ABL fusion gene has been characterized for 122 chronic myeloid leukemia patients.

Breakpoint cluster region (BCR) is a gene that functions as a fusion partner with ABL1 to encode a fusion protein that is a result of the reciprocal translocation between chromosomes 22 and 9. The translocation produces the Philadelphia chromosome - a hallmark feature of chronic myelogenous leukemia (CML).

Apr 7, 2025 · Chronic myeloid leukemia (CML) is a kind of leukemia that arises due to the translocation betwixt chromosomes 9 and 22. Philadelphia chromosome is characterized by the BCR::ABL fusion gene, which results from this recombination. It transcribes into active tyrosine kinase variants such as P185, P190, …

Apr 14, 2025 · Oncogenic gene fusions occur frequently (or are a defining feature) in certain types of cancer. 6, 7, 8 For example, the BCR-ABL fusion – which gives rise to an aberrant, constitutively active ...