The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor is composed of a membrane-bound immunoglobulin molecule and a signal transduction moiety.

Apr 11, 2025 · The B cell antigen receptor (BCR) is composed of membrane immunoglobulin (mIg) molecules and associated Igα/Igβ (CD79a/CD79b) heterodimers (α/β). The mIg subunits …

Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to …

Each B cell occupies a unique B cell receptor (BCR), and all BCRs throughout our body form “BCR repertoire.” With the development of sequencing technology and coupled bioinformatics, …

B cells identify antigens by their surface B cell receptor (BCR), which upon stimulation, directs the cell to activate and differentiate into antibody generating plasma cells.

Jul 8, 2019 · BCR signaling has been shown to govern the initiation of transcriptional programs associated with B cell activation and fate decisions, as well as the BCR-dependent processing …

Apr 3, 2025 · The combined application of single-cell RNA sequencing (scRNA-seq) and single-cell B-cell receptor sequencing (scBCR-seq) offers a multidimensional perspective for …

Mar 14, 2025 · B cell receptor (BCR) signaling is essential for the adaptive immune response, guiding B cells in recognizing antigens and initiating immune defense. This process ensures …

The B cell receptor (BCR) covers the surface of mature B cells, and initiates cellular responses that lead to B cell activation and antibody production. Each B cell expresses a unique B cell …

Aug 18, 2022 · The BCR is a multifunctional machine that is responsible for regulating most functions of a B cell. Under the appropriate conditions, antigen binding triggers B cell …