BCL11A - Wikipedia
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene. [5][6][7] The BCL11A gene encodes for a regulatory C2H2 type zinc-finger protein, that can …
Bcl11a maintains hematopoietic stem cell function but ... - Science
Apr 11, 2025 · In Bcl11a-MUT mice, the ratio remained stable at 2:1 across five lineages . However, in Bcl11a-WT mice, the ratio increased in myeloid and B cells, with no dramatic …
BCL11A Gene - GeneCards | BC11A Protein | BC11A Antibody
Mar 28, 2025 · This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration …
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β …
Dec 5, 2020 · BCL11A is a transcription factor that represses γ-globin expression and fetal hemoglobin in erythroid cells. We performed electroporation of CD34+ hematopoietic stem …
BCL11A: a potential diagnostic biomarker and therapeutic
Nov 29, 2019 · BCL11A functions mainly as a transcriptional repressor that is crucial in brain, hematopoietic system development, as well as fetal-to-adult hemoglobin switching. The …
Multimeric transcription factor BCL11A utilizes two zinc ... - Nature
6 days ago · BCL11A, a transcription factor, is vital for hematopoiesis, including B and T cell maturation and the fetal-to-adult hemoglobin switch. Mutations in BCL11A are linked to …
BCL11A BCL11 transcription factor A [ (human)] - National Center …
Feb 8, 2025 · This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration …
Role of B-Cell Lymphoma/Leukemia 11A in Normal and Malignant …
Jan 1, 2025 · B-cell lymphoma/leukemia 11A (BCL11A) is a crucial transcriptional regulator, widely recognized for its role in controlling fetal hemoglobin and its potential as a gene therapy …
Functional studies of BCL11A: characterization of the conserved BCL11A …
Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. …
BCL11A (B-cell lymphoma/leukemia 11A)
Apr 1, 2002 · Three children with different de novo BCL11A variants and diverse developmental phenotypes, but shared global motor discoordination and apraxic speech: Evidence for a …