In this paper, we review current knowledge on blood-brain barrier (BBB) dysfunction following intracerebral hemorrhage (ICH). BBB disruption is a hallmark of ICH-induced brain injury.

Glibenclamide maintained BBB integrity in experimental ICH by inhibiting the activation of the NLRP3 inflammasome in microvessel endothelial cells. Our findings will contribute to elucidating the pharmacological mechanism of action of glibenclamide and to …

This article reviews current knowledge of the mechanisms underlying the initial hemorrhage and secondary blood–brain barrier (BBB) dysfunction in primary spontaneous intracerebral hemorrhage (ICH) in adults.

Jan 21, 2022 · Associated with neurobehavioral benefits, Met-R exhibited protective effects on BBB integrity after ICH, as evidenced by reduced albumin expression and Evans blue dye extravasation in brain parenchyma, as well as the preservation of tight junction protein expression after ICH in mice.

Expressions of the tight junction markers, ZO-1, claudin-5, and occludin were downregulated 1 to 3 days from onset in both collagenase and blood injection models of ICH [250-258]. Clinically, BBB permeability in patients with ICH increases after 24 h of onset .

Jul 19, 2017 · In the current study, we investigated the role of Mfsd2a in BBB injury induced by ICH. Our results indicate that selectively expressing endothelial Mfsd2a suppresses ICH‐induced BBB disruption by inhibiting vesicular transcytosis.

Jul 8, 2022 · Specifically, we summarize the evidence and the underlying mechanisms, including the ICH-induced process of oxidative stress and inflammatory response, and we highlight the potential therapeutic targets to protect BBB integrity after ICH.

Sep 26, 2021 · Frizzled-7 activation potentially attenuated BBB permeability and improved neurological deficits after ICH through Dvl /β-Catenin/WISP1 pathway. Frizzled-7 may be a potential target for the development of ICH therapeutic drugs.

Jan 1, 2023 · ICH-induced brain injury also induces blood-brain barrier (BBB) disruption and parenchymal cell swelling causing perihematomal edema (PHE). This can increase intracranial pressure (ICP), potentially leading to brain injury, herniation and death.

Oct 8, 2021 · AHR inhibition provided neurological benefits by restricting HE and preserving BBB function after hyperglycemic ICH. In vivo knockdown of AHR further limited HE and enhanced the BBB integrity. Hyperglycemia directly activated AHR as a physiological stimulus in vivo.