The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
Several genomic studies have revealed that ∼20% of malignancies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF …
The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
Aug 1, 2016 · We review several roles of BAF and PBAF complexes in cancer, including transcriptional regulation, DNA repair, and regulation of chromatin architecture and topology. …
Structure of nucleosome-bound human PBAF complex
Dec 10, 2022 · BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free …
The SWI/SNF chromatin remodeling complexes BAF and PBAF
Jun 13, 2023 · Depletion of the canonical SWI/SNF form, BAF, impaired initial CD8 + T cell responses in acute and chronic infection. In contrast, disruption of PBAF enhanced Tex-cell …
The SWI/SNF PBAF complex facilitates REST occupancy at …
4 days ago · Further complicating the functional dissection of individual SWI/SNF complexes is the modular nature of these macromolecular assemblies that generally exist in three distinct …
The SWI/SNF chromatin remodeling complexes BAF and PBAF …
Jun 13, 2023 · Together, BAF and PBAF cooperated to epigenetically regulate Tex subset differentiation. Depleting PBAF improved antitumor immunity, an effect further enhanced by …
Structure of nucleosome-bound human BAF complex - PubMed
Feb 21, 2020 · Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, …
Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in …
Two of the main human SWI/SNF complexes are BRG1 associated factors, BAF and Polybromo-associated BAF, PBAF. They share a conserved set of nine proteins, including the catalytic …
Several genomic studies have revealed that 20% of malignan-cies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) …
Structure of nucleosome-bound human PBAF complex - PMC
BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for …