Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain, and are crucial for cells to be able to efficiently bind to the extracellular matrix. [5] . This is especially …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d) and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α subunit defines …

Jun 16, 2022 · Here, we review recent structural and functional insights into how talin-1 and kindlin-3 enable integrin activation, with a focus on the distal signaling components that trigger …

β2 integrins, also known as leukocyte integrins [4, 27], are the most important molecules in recruiting leukocytes, especially neutrophils and naïve lymphocytes, from the blood stream to …

Integrins comprise a large family of αβ heterodimeric cell adhesion receptors that are expressed on all cells except red blood cells and that play essential roles in the regulation of cell growth …

Dec 20, 2017 · Through these three processes, β 2 integrins both contribute to and regulate immune responses. This review explores the pro- and anti-inflammatory effects of β 2 integrins …

Feb 19, 2019 · Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for leukocyte (e.g., neutrophil, lymphocyte) trafficking, as well as for other …

Jul 28, 2021 · Integrin β2 is one of the most commonly expressed integrins in leukocytes that mediate leukocyte adhesion and migration, and it plays an important role in immune …

Jun 16, 2022 · Here, we review recent structural and functional insights into how talin-1 and kindlin-3 enable integrin activation, with a focus on the distal signaling components that trigger …

Aug 1, 2021 · Integrin β2 is one of the most commonly expressed integrins in leukocytes that mediate leukocyte adhesion and migration, and it plays an important role in immune …