APC controls Wnt-induced β-catenin destruction complex
Feb 19, 2020 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor …
Apc, wnt signaling pathway regulator - Wikipedia
APC, WNT signaling pathway regulator is a protein that in humans is encoded by the APC gene. [4] This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt …
Wnt/β-catenin signalling: function, biological mechanisms, …
Jan 3, 2022 · Recently, Ji et al. found that ICAT is a natural inhibitor of APC that plays a positive role in Wnt signal transduction by blocking APC-mediated degradation of β-catenin.
Mutant APC reshapes Wnt signaling plasma membrane …
Jul 19, 2023 · Here, we demonstrate the role of oncogenic APC in increasing plasma membrane free cholesterol and rigidity, thereby modulating Wnt signaling hubs. This results in an …
Wnt signaling in cancer: from biomarkers to targeted therapies …
Apr 2, 2025 · Adenomatous polyposis coli (APC) APC is a tumor suppressor gene that regulates β-catenin degradation [65, 66].However, alterations in the APC gene impair Wnt signaling …
Functions of the APC tumor suppressor protein dependent and independent ...
By negatively regulating canonical WNT signaling, APC counteracts proliferation, promotes differentiation, facilitates apoptosis and suppresses invasion and tumor progression. APC …
The canonical Wnt signalling pathway and its APC partner in …
Wnt growth factors activate a cascade of intracellular events, which is known as the canonical Wnt pathway that ultimately leads to the expression of a genetic program controlling the …
APC controls Wnt-induced β-catenin destruction complex
Feb 19, 2020 · APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this complex is inhibited. However, …
USP7 Is a Tumor-Specific WNT Activator for APC-Mutated …
Oct 17, 2017 · The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt …
An APC:WNT Counter-Current-Like Mechanism Regulates Cell …
Nov 7, 2013 · APC normally down-regulates WNT signaling in human colon, and APC mutations cause proliferative abnormalities in premalignant crypts leading to colon cancer, but the …