Hepatic and circulating BMP6 expression was assessed in APAP-treated mice and in serum samples from patients with APAP overdose. In addition, BMP6 expression and release was evaluated in hepatocytes after APAP exposure.

We found that a methane-rich medium decreased the levels of reactive oxygen species (DHE fluorescent staining), inhibited apoptosis (cell flow test), and regulated the Nrf2/HO-1/NQO1 signaling pathway.

Jun 1, 2020 · Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid compound, has been revealed to exert multiple pharmacological activities.

Acetaminophen (N-acetyl-p-aminophenol, APAP, paracetamol, Tylenol ®) is a ubiquitous and highly utilized over-the-counter medication for relief of pain and fever that is also a dose-related toxin. 1 APAP toxicity accounts for 46% of all acute liver failure (ALF) in the United States 2 and between 40 and 70% of all cases in Great Britain and ...

Aug 19, 2024 · The results showed that APAP administration significantly increased DHE fluorescence intensity in the liver sections of WT mice, but the liver sections of SIRT5-KO mice exhibited higher DHE intensity than those of WT mice (Figure 4D,O).

Download scientific diagram | EGM NPs scavenge ROS to alleviate APAP-induced liver injury. (A) DHE staining (red fluorescence), DAPI (blue fluorescence) staining, and their merge images of...

Jan 10, 2025 · Oxidative stress is an important cause of acetaminophen (APAP)-induced liver injury (AILI). Sakuranetin (Sak) is an antitoxin from the cherry flavonoid plant with good antioxidant effects. However, whether sakuranetine has a protective effect on APAP-induced liver injury is not clear.

Dec 1, 2024 · Artemisia argyi essential oil (AAEO), a volatile oil component extracted from traditional Chinese medicine Artemisia argyi H.Lév. & Vaniot, has great hepatoprotective effects. However, the potential role of AAEO in APAP-induced hepatotoxicity has not been characterized.

Our present study revealed that APAP induced significantly elevated ROS production in Ppara fl/fl mice but diminished ROS production in almost all Ppara ΔHep mice, as evidenced by the markedly lower levels of hepatic MDA content and decreased number of DHE-positive cells. Thus, hepatocyte-specific PPARα deficiency protects against APAP ...

Nov 15, 2024 · Macrophages attenuate APAP acute liver injury by regulating the inflammatory response and activating necrotic apoptosis-related pathways. The inflammatory response is a significant factor in acetaminophen (APAP)-induced acute liver injury. And it can be mediated by macrophages of different origins.