S6K1-mediated phosphorylation of PDK1 impairs AKT kinase
Mar 22, 2022 · Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), …
Akt–RSK–S6 Kinase Signaling Networks Activated by ... - Science
Aug 24, 2010 · We developed a large-scale proteomic approach to identify more than 300 substrates of this kinase family in cancer cell lines driven by the c-Met, epidermal growth factor …
Balancing Akt with S6K - PMC - National Center for Biotechnology ...
Nov 8, 2004 · Akt-directed phosphorylation of tuberin relieves its inhibition of TOR, via activation of the small G protein Rheb (not depicted). TOR activation by this pathway requires the …
Robust anti-myeloma effect of TAS0612, an RSK/AKT/S6K
Oct 22, 2024 · In this study, we revealed that the triple targeting of RSK, AKT, and S6K by TAS0612 leads to the modulation of various pathophysiologically and clinically important …
Beyond controlling cell size: functional analyses of S6K in ... - Nature
Jul 25, 2022 · As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …
Triple targeting of RSK, AKT, and S6K as pivotal downstream
These results prove that the simultaneous blockade of RSK2, AKT, and S6K, which are the pivotal downstream substrates of PDPK1, is a novel therapeutic target for the various disease …
mTOR, S6 and AKT expression in relation to proliferation and ... - PubMed
Background: The mammalian target of rapamycin (mTOR) controls cell growth through protein synthesis regulation. It can be activated by protein kinase B (AKT) or through ribosomal S6 …
Balancing Akt with S6K | Journal of Cell Biology | Rockefeller ...
Nov 8, 2004 · Proper regulation of the phosphoinositide 3-kinase–Akt pathway is critical for the prevention of both insulin resistance and tumorigenesis.
Balancing Akt with S6K: implications for both metabolic ... - PubMed
Nov 8, 2004 · Proper regulation of the phosphoinositide 3-kinase-Akt pathway is critical for the prevention of both insulin resistance and tumorigenesis.
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 …
Aug 8, 2016 · In this work we show that, upon PI3Kα inhibition, the PDK1-SGK1 axis can overcome AKT inhibition by activating mTORC1 via direct phosphorylation of TSC2. …