Here, we summarize the current knowledge about AhR signaling pathways, its ligands and AhR-mediated effects on cell specialization, host defense and detoxification. AhR-mediated health effects particularly in liver, immune, and nervous systems, as well as …

Mgta-456, an aryl hydrocarbon receptor (AHR) antagonist based expansion of CD34+ hematopoietic stem cells (HSC), permits selection of better HLA matched cord blood units (CBUs) and promotes faster neutrophil recovery and uniform engraftment with potentially less acute graft-vs-host disease (GVHD).

Several studies indicate that murine and human HSC express modest AhR levels [98–100] and recent breakthrough studies indicate that the AhR plays a critical role in HSC growth and differentiation [95, 101–105].

Oct 1, 2019 · In stem cell proliferation assay, compound 5b elicited marked HSC expansion. 1. Introduction. The aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to a family of basic helix-loop-helix/Per-Arnt-Sim (b-HLH/PAS) …

Jul 18, 2013 · Using a novel, pluripotent stem cell–based, chemically-defined, serum and feeder cell–free culture system, we show that the AhR is expressed in HPs and that, remarkably, AhR activation drives an unprecedented expansion of HPs, megakaryocyte-lineage cells, and erythroid-lineage cells.

Jul 24, 2015 · Lack of aryl hydrocarbon receptor (AhR) has been associated with alterations in gene expression related to HSC function and the subsequent development of a myeloproliferative disorder in aging female mice.

Feb 15, 2004 · Our results demonstrate that C. elegans ahr-1 functions as a cell-type specific determinant. This study further supports the notion that the ancestral role of the AHR proteins is in regulating cellular differentiation in animal development.

Sep 10, 2010 · Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AhR). The identification of SR1 and AhR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.

Dec 7, 2017 · We have demonstrated that AHR antagonism is an effective strategy to expand functional HSCs and that novel small molecules inhibiting AHR can expand gene modified HSCs from mPB and BM. Studies are ongoing to confirm expansion with our proprietary compound of HSCs transduced with lentiviral vectors also leads to improved engraftment.

Sep 10, 2010 · Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo HSC expansion should facilitate the clinical use of HSC therapy.