A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme [4] that in humans is encoded by the ADAMTS2 gene. [5][6] The ADAMTS2 gene is located on the long (q) arm of chromosome 5 at the end (terminus) of the arm, from base pair 178,473,473 to base pair 178,704,934.

The ADAMTS2 gene provides instructions for making an enzyme that processes several types of procollagen molecules. Learn about this gene and related health conditions.

Mar 28, 2025 · ADAMTS2 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2) is a Protein Coding gene. Diseases associated with ADAMTS2 include Ehlers-Danlos Syndrome, Dermatosparaxis Type and Marfan Syndrome And Marfan-Related Disorders. Among its related pathways are O-linked glycosylation of mucins and Collagen chain trimerization.

ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. [1] 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. [2] .

ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V procollagens.

Dec 10, 2024 · Go to complete Gene record for ADAMTS2; Go to Variation Viewer for ADAMTS2 variants; Summary. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.

Pro-collagen I N-proteinase is now referred to as ADAMTS2. Furthermore, five ADAMTSL genes have recently been identified. These members lack the PD, MP and DIS domains found in other ADAMTS proteins; however, the remaining domain organisation is remarkably similar.

May 1, 2015 · ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers–Danlos syndrome. ADAMTS2 and 3 are regulators of blood vessels homeostasis and lymphangiogenesis. Larger repertoire of substrates and functions are likely for these ADAMTS.

ADAMTS-2 is a metalloproteinase that plays a key role in the processing of fibrillar procollagen precursors into mature collagen molecules by excising the amino-propeptide.

As dramatically seen in the dermatosparactic type of EDS, ADAMTS2 is crucial for fibrillar collagen maturation. This largely explain why most of the studies about ADAMTS2, but also about its closest relatives ADAMTS3 and ADAMTS14, have been mainly focused on collagen and extracellular matrix biology.