Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is stored in the acrosome in its precursor form, proacrosin. Upon stimulus, the acrosome releases its contents onto the zona pellucida.

Acrosin is presently believed to be responsible for the dispersal of the acrosomal contents during acrosome reaction (Yamagata et al., 1998). The acrosome must release its contents in order to facilitate fertilization.

In addition to the typical elements of serine proteases, the acrosin molecule possesses one novel domain that might convey DNA-binding properties. The sperm enzyme acrosin has long been known as one of the key enzymes in the mammalian fertilization process.

Elucidation of primary structures of preproacrosin from various species have allowed a deeper insight into the structural organization and the complex evolution of the sperm proteinase acrosin. In addition to the typical elements of serine proteases, the acrosin molecule possesses one novel domain that might convey DNA-binding properties.

Mar 30, 2025 · Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin.

A serine proteinase in sperm (spermatozoa) similar in specificity to trypsin. A sperm serine protease encoded by ACR, which is formed from proacrosin by cleavage at lysine and arginine, and inhibited by antitrypsins. Acrosin lyses the ovum’s zona pellucida, facilitating sperm penetration through the innermost glycoprotein layers of the ovum.

Aug 31, 2023 · Acrosin (EC 3.4.21.10) is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin.

Apr 13, 2024 · Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin.

Acrosin is responsible for the serine protease activity associated with the IAM. In order to show that the serine protease activity associated with the detergent extract of the SSpH is due to acrosin, we raised an antibody against a specific peptide region common to …

Acrosin (ACR) is an intra-acrosomal protein involved in secondary binding between the spermatozoa and zona pellucida-binding proteins (Howes and Jones, 2002). From: The Veterinary Journal, 2010