May 29, 2017 · Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778 (G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism...

Jan 25, 2024 · ACKR1/DARC-associated neutropenia (NP; ADAN; Online Mendelian Inheritance in Man 611862), caused by a variation in the ACKR1/DARC gene (rs2814778), is common in persons of African or Middle Eastern descent.

May 7, 2024 · It is now firmly recognized that a family of receptors known as atypical chemokine receptors (ACKRs) 1 has an important role in regulation of the chemokine system and leukocyte migration in...

Jul 7, 2022 · Duffy antigen receptor for chemokines (DARC)/CD234, also known as atypical chemokine receptor 1 (ACKR1), is a seven-transmembrane domain protein expressed on erythrocytes, vascular endothelium, and a subset of epithelial cells (Peiper et al., 1995). Previously, we reported that ACKR1 was expressed in bone marrow macrophages.

May 19, 2017 · We hypothesized that the atypical chemokine receptor DARC (Duffy Antigen Receptor for Chemokines, a.k.a. ACKR1 or CD234) may distinguish V-ECs versus NV-ECs in mice. Methods: We generated a rat-anti-mouse monoclonal antibody (MAb) that specifically recognizes the erythroid and endothelial forms of native, surface-expressed DARC.

Mar 30, 2025 · ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Diseases associated with ACKR1 include White Blood Cell Count Quantitative Trait Locus 1 and Malaria. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Sep 15, 2021 · We confirmed upregulation of ACKR1 protein in pMBMECs promoting transcellular T-cell diapedesis and in venular endothelial cells in the CNS during EAE. Lack of endothelial ACKR1 reduced transcellular T-cell diapedesis across pMBMECs under physiological flow in vitro.

Jun 5, 2015 · Recently, a new nomenclature for atypical non-signaling chemokine receptors such as DARC was adopted and approved and DARC is now known by the acronym ACKR1 (atypical chemokine receptor 1) (7) However, for the purpose of this review, we will stick to the old nomenclature of DARC.

In this study we have developed and validated a novel sensitive real-time RT-PCR assay for the detection of all four HEV genotypes. Simultaneous discrimination of genotypes 1, 2, and 4 from genotype 3 by single nucleotide polymorphism (SNP) analysis was possible.

Jun 5, 2023 · The following genetically modified mice were used in the study: -/-Acrk1 78 (Ackr1tm1Scp/Mmnc, gift of Stephen Peiper) (Dawson et al., 2000), Ackr2-/-(B6.129/Sv-79 Ccbp2tm1Gjg/Apb, gift of Gerard Graham) (Jamieson et al., 2005), Camp-/ …