Live Cell Analysis of Aquaporin-4 M1/M23 Interactions and …
Dec 18, 2009 · By studying co-expressed M23 and M1 cysteine mutants here, we found that M1 palmitoylation does significantly alter AQP4 assembly at physiological temperature, not by …
Membrane organization and function of M1 and M23 isoforms of ... - PubMed
Aquaporin-4 (AQP4) water channels exist as heterotetramers of M1 and M23 splice variants and appear to be present in orthogonal arrays of intramembraneous particles (OAPs) visualized by …
Regulation of aquaporin-4 expression in the central nervous …
We hypothesize a role of the M23-AQP4 in the regulation of M1-AQP4 expression. M1-AQP4 transcription, splicing and M1-AQP4 protein degradation were found to be unaffected in M23 …
Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA ... - PubMed
Jul 29, 2014 · NMO-IgG/AQP4-Ab seropositivity in patients with NMO and its spectrum disorders has important differential diagnostic, prognostic and therapeutic implications. So-called cell …
Aggregation state determines the localization and function of M1…
Feb 2, 2014 · Here, we demonstrate that the AQP4 aggregation state determines its subcellular localization and cellular functions. Individually expressed M1–AQP4 was freely mobile in the …
Aquaporin-4 square array assembly: Opposing actions of M1 and …
The relevance of AQP4 square array assembly to the physiology and pathophysiology of brain is unknown. Our studies suggest that M1 and M23 may restrict AQP4 square array assembly to …
Thermodynamics and S-Palmitoylation Dependence of …
Jan 11, 2024 · Aquaporin-4 (AQP4) is a water channel protein found primarily in the central nervous system (CNS) that helps to regulate water–ion homeostasis. AQP4 exists in two …
Live Cell Analysis of Aquaporin-4 M1/M23 Interactions and …
By studying co-expressed M23 and M1 cysteine mutants here, we found that M1 palmitoylation does significantly alter AQP4 assembly at physiological temperature, not by altering the ability …
Aquaporin-4: orthogonal array assembly, CNS functions, and
May 9, 2011 · The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called …
Live cell analysis of aquaporin-4 m1/m23 interactions and ... - PubMed
Dec 18, 2009 · Here, we studied M1/M23 interactions and regulated OAP assembly by nanometer-resolution tracking of quantum dot-labeled AQP4 in live cells expressing …