The impact of CYP2D6 mediated drug-drug interaction: a ... - PubMed
Aim: Metoprolol (a CYP2D6 substrate) is often co-prescribed with paroxetine/fluoxetine (a CYP2D6 inhibitor) because the clinical relevance of this drug-drug interaction (DDI) is still …
Prediction of Drug-Drug Interactions with Bupropion and Its …
These DDI predictions may explain the occurrence of severe sinus bradycardia after coadministration of bupropion and metoprolol and highlight the need for caution and dosage …
A Comprehensive CYP2D6 Drug-Drug-Gene Interaction Network …
The cytochrome P450 (CYP) 2D6 enzyme is particularly prone to DDGIs due to the high prevalence of genetic variation and common use of CYP2D6 inhibiting drugs. In this study, we …
In vitro to in vivo extrapolation of the complex drug-drug …
The aim of this study was to quantitatively explain the in vivo CYP2D6 DDI magnitude by in vitro DDI data. Bupropion and its metabolites were found to inhibit CYP2D6 stereoselectively with …
A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network …
Feb 14, 2025 · In this study, we present a comprehensive PBPK network covering CYP2D6 drug–gene interactions (DGIs), DDIs, and DDGIs. The network covers sensitive and moderate …
A Scoping Review of the Evidence Behind CYP2D6 Inhibitor ...
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) contributes to 2% and 0.7% of the overall hepatic and intestinal cytochrome P450 enzyme, respectively, and is estimated to be …
Projections of Drug-Drug Interactions Caused by Time-Dependent …
Feb 26, 2024 · In vitro time-dependent inhibition (TDI) kinetic parameters for cytochrome P450 (CYP) 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6, were determined in pooled human liver …
The impact of CYP2D6 mediated drug–drug interaction: a ... - Wiley
Sep 24, 2018 · Metoprolol (a CYP2D6 substrate) is often co-prescribed with paroxetine/fluoxetine (a CYP2D6 inhibitor) because the clinical relevance of this drug–drug interaction (DDI) is still …
Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib …
Jan 1, 2021 · CYP screening showed that CYP3A4, 1A2, and 2D6 were the three most significant isoenzymes contributing to erlotinib metabolism. With fluoxetine’s known potent (strong) …
Prediction of CYP2D6 Drug Interactions from In Vitro Data: …
The in vivo sensitivities of the clinically relevant CYP2D6 substrates desipramine, dextromethorphan, and metoprolol were determined on the basis of literature drug-drug …
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