Factor (F) VIII is a large gene located near the terminus of the long arm of the X chromosome. It contains 26 exons that code for a signal peptide and a 2332 amino acid polypeptide with three different types of domains, namely A1-A2-B-A3-C1-C2.

Dec 1, 1998 · Its transcription may require several hours assuming a transcription rate of 10 nucleotides per second, and yields a 9-kb mRNA product. 5 The factor VIII gene comprises 26 exons, which encode a polypeptide chain of 2351 amino acids. 6-8 This includes a signal peptide of 19 and a mature protein of 2332 amino acids.

Sep 12, 2021 · EML4 contains 26 exons and there are many different fusion partners with various deletions and insertions. The majority have been found to have exon 1-13 fused with exon 20 of ALK. This was the original version described in 2007 and it was called variant 1.

The F8 gene contains 26 exons and spans 186 kb (Gitschier et al., 1984). Levinson et al. (1990) found a curious example of a gene within a gene. In looking for transcripts from the Xq28 region, they found one referred to as the A gene that hybridized to a region in exon 22 of the F8 gene.

A notable example is the human gene that encodes the blood clotting protein factor VIII. This gene contains about 186 kb of DNA and is divided into 26 exons. The mRNA is only about 9 kb long, which implies that about 175 kb of the gene contains introns.

Oct 5, 2023 · It is one of the largest known genes, divided into 26 exons that span 186,000 base pairs [1,2]. Factor VIII is synthesized as a single chain polypeptide of 2351 amino acids.

Jun 5, 2024 · Sequencing revealed the presence of 26 exons that ranged from 69 bp to 3,106 bp in length, and introns as large as 32.4 kb. At the time, this gene was the largest that had been...

The F8 gene contains 26 exons spread over approximately 186 kb and no work using the intact genomic locus has been carried out. We have constructed a 250-kb BAC carrying all 26 exons, the introns, and more than 40 kb of upstream and 20 kb of downstream DNA.

Mar 1, 2003 · Factor (F) VIII is a large gene located near the terminus of the long arm of the X chromosome. It contains 26 exons that code for a signal peptide and a 2332 amino acid polypeptide with three...

Aug 10, 2021 · Hemophilia A is an X-linked recessive disorder caused by a deficiency in factor VIII (FVIII). The FVIII gene is located on the long arm of the X chromosome (Xq28). It is 187 kilobases (kb) in size and composed of 26 exons.