IRF3 regulates neuroinflammatory responses and the expression …
Aug 30, 2024 · Using bulk-RNAseq of IRF3-2D brain myeloid cells, we identified Z-DNA binding protein-1 (ZBP1) as a target of IRF3 that is relevant across various neuroinflammatory …
IRF3 inhibits inflammatory signaling pathways in macrophages
Aug 9, 2024 · IRF3, a critical component of innate antiviral immune responses, interacts with pro-inflammatory transcription factor NF-κB, and inhibits its activity. This mechanism helps …
DNA-PK inhibition sustains the antitumor innate immune response …
Mar 21, 2025 · IF analysis revealed an increase in the mean fluorescence intensity (MFI) of STING and MAVS along with a significant increase of their co-localization in DNA-PKi-treated …
Antiviral innate immune memory in alveolar macrophages …
Sep 30, 2024 · Alveolar macrophages that previously experienced polyIC showed significantly increased levels of nuclear IRF3 upon restimulation with polyIC (polyIC/polyIC) compared with …
IL-10 targets IRF transcription factors to suppress IFN and ... - Nature
1 day ago · IL-10 is a key suppressor of innate immune activation and inflammatory responses. A well-recognized mechanism of IL-10 action is the suppression of nuclear factor-κB (NF-κB) …
Human OTUD6B positively regulates type I IFN antiviral innate
Aug 31, 2023 · Confocal microscopy showed that more IRF3 translocated to the nucleus with overexpressing OTUD6B upon viral infection as measured using mean fluorescence intensity …
Induction of Proinflammatory Cytokines in Primary Human …
Jan 15, 2009 · In comparison with human influenza (H1N1), the H5N1 virus more strongly activated IFN regulatory factor 3 (IRF3). IRF3 knockdown and p38 kinase inhibition separately …
IRF3 promotes adipose inflammation and insulin resistance and …
Aug 1, 2016 · Here, we determined that IRF3 expression is upregulated in the adipocytes of obese mice and humans. Signaling through TLR3 and TLR4, which lie upstream of IRF3, …
The multiple roles of interferon regulatory factor family in health …
Oct 9, 2024 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, IRF6, …
Revisiting the role of IRF3 in inflammation and immunity by ... - PNAS
For this study, we generated conditional Irf3 -deficient mice while leaving the Bcl2l12 gene intact. Conditional ablation of IRF3 in myeloid cells showed increased survival when challenged with …