Jan 8, 2015 · Interleukin-6 (IL-6) is one of the most critical tumor-promoting cytokines in non-small cell lung cancer (NSCLC). In our recent study, we confirmed that NADPH oxidase 4 (NOX4), …

Selective NOX1 inhibition rescues age-impaired blood flow and angiogenesis, abrogates senescence, and restores vascular function. NF-κB and peroxisome proliferator–activated …

Secretion of the TH1-promoting cytokine IL-12 and other pro-inflammatory cytokines including IL-6, Tumor necrosis factor (TNF) and IL-1β is inhibited by NOX2 [50,75,127,129,130].

Oct 19, 2021 · In an inquiry into signaling triggered by aging and proxy instigator, hyperglycemia, we show that NADPH Oxidase (NOX) drives cell DNA damage and alters nuclear envelope …

IL-6 has direct effects on endothelial nitric oxide synthase activity and expression as well as increasing vascular superoxide, which rapidly inactivates NO thereby limiting NO bioavailability.

Sep 18, 2018 · Our findings showed that LysoPC-induced COX-2-dependent IL-6 expression is mediated through NOX/ROS/JNK1/2 leading to FoxO1 S256 and NF-κB activation (Fig. 8 d). …

Aug 8, 2013 · IL-6 and its effect on the innate and adaptive immune response have been shown to be required for protection against Candida, Yersinia enterocolitica, L. monocytogenes, and …

Upregulation of NRROS on the hydrogen peroxide (H 2 O 2)-mediated ROS generation and interleukin 6 (IL-6) secretion was measured. 15d-PGJ 2-induced NRROS expression was …

Taken together, we demonstrate a constitutive NOX4-dependent ROS generation in a microglial cell line which leads to expression of IL-6 mRNA.

IL-6 is a soluble mediator with a pleiotropic effect on inflammation, immune response, and hematopoiesis. At first, distinct functions of IL-6 were studied and given distinct names based …