Nov 23, 2023 · Solubility in water: 1500 g/L (25 °C); pKa - 2,18; pKb - 8,95 Rf value in n-butanol/acetic acid/water = 12:3:5 - 0.14 2D Molfile: Get the molfile 3D PDB file: Get the PDB file Other names: alpha-Lysine; (+)-S-Lysine; (S)-2,6-Diamino-hexanoic acid. What are the functions of …

Amino Acid Abbreviation Structure MW pKa (25 °C) pI (25° C) -CO2H -NH2 sidechain Alanine Ala A 89.10 2.35 9.87 6.11 Arginine Arg R 174.20

Mar 9, 2011 · To examine molecular determinants of their unusual and functionally important properties, we engineered 25 variants of staphylococcal nuclease with lysine residues at internal positions. Nineteen of the Lys residues have depressed pK a values, some as low as 5.3, and 20 titrate without triggering any detectable conformational reorganization.

Lysine. an essential amino acid, has a positively charged ε-amino group (a primary amine). Lysine is basically alanine with a propylamine substituent on theβcarbon. The ε-amino group has a significantly higher pK a (about 10.5 in polypeptides) than does the α-amino group.

The average pKa of Lys is 8.54, which is 2.14 pK unit lower than the average pKa found in wild-type protein (10.68). Figure 3a indicates that the pKa values for Lys can vary from 5 to 11 with a significant probability at 6 and 7.

We tabulated 541 measured pK values reported in the literature for the Asp, Glu, His, Cys, Tyr, and Lys side chains, and the C and N termini of 78 folded proteins. The majority of these values are for the Asp, Glu, and His side chains.

Mar 29, 2011 · To examine molecular determinants of their unusual and functionally important properties, we engineered 25 variants of staphylococcal nuclease with lysine residues at internal positions. Nineteen of the Lys residues have depressed pK (a) values, some as low as 5.3, and 20 titrate without triggering any detectable conformational reorganization.

... average pKa of Lys is 8.54, which is 2.14 pK unit lower than the average pKa found in wild-type protein (10.68). Figure 3 a indicates that the pKa values for Lys can vary from 5 to 11 with a...

The pKa value of the ε-amino group of Lys is approximately 10.5, which is higher than the pKa values of the carboxyl and α-amino groups. At physiological pH (around 7.4), the ε-amino group of Lys is predominantly protonated, giving Lys a net positive charge.

Feb 6, 2015 · The pka of the both aminogroups is much higher than your pH of 5, so both are protonated. You have two positive charges. The carboxylic acid is deprotonated at pH 5 because its pka is 2.18.