6 days ago · Phospho-EGF Receptor (Tyr1068) Antibody detects endogenous levels of EGF receptor only when phosphorylated at tyrosine 1068. The antibody may cross-react with other activated EGF receptor family members (e.g. ErbB2), and cross-reacts slightly with activated PDGF receptor .

Mar 28, 2024 · p-EGFR Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects phosphorylated Tyr 1092 of EGFR of human origin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-EGFR monoclonal antibody ...

Invitrogen Anti-Phospho-EGFR (Tyr1068) Polyclonal, Catalog # 44-788G. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) applications. This antibody reacts with Human, Rat samples. Supplied as 100 µL purified antibody.

Phosphorylated EGFR (p-EGFR) activates cell signaling pathways and has implications in cell cycle, apoptosis, angiogenesis, and cell proliferation. [11, 12] It has been shown that EGFR and p-EGFR are esstential in the carcinogenesis and development of nasopharyngeal carcinoma.

Aug 6, 2015 · Here, we investigated erlotinib response of lung CSCs with WT-EGFR and identified EGFR phosphorylation at tyrosine1068 (EGFR tyr1068) as a powerful biomarker associated with erlotinib...

Feb 28, 2020 · p-EGFR Antibody (12A3) is a mouse monoclonal IgG1 antibody that detects Tyr 845 phosphorylated EGFR in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). p-EGFR monoclonal antibody (12A3) is available in a non-conjugated form, providing researchers with a versatile tool for studying the epidermal growth ...

In this review we emphasize how recent EGFR kinase domain crystal structures can explain the mechanisms of activation for L858R and other EGFR-TK mutations, and compare these distinct activating mechanisms with those recently described for the wild-type EGFR.

Dec 3, 2023 · The epidermal growth factor receptor (EGFR) family is a subclass of receptor tyrosine kinase (RTK) proteins and consists of 4 members: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3) and ErbB4 (HER4).

Here, we review the molecular mechanisms that regulate EGFR signal transduction, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the signaling pathways that lead to G1 cell cycle progression.

p-EGFR (12A3) is a mouse monoclonal antibody raised against an EGFR phosphopeptide of human origin. Each vial contains 50 μg IgG1 in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose.