Nitisinone, sold under the brand name Orfadin among others, is a medication used to slow the effects of hereditary tyrosinemia type 1 (HT-1). It is available as a generic medication. [2][3]

Feb 1, 2025 · Nitisinone is used to treat hereditary tyrosinemia type 1, which is too much tyrosine in the blood. It helps to prevent high levels of tyrosine in the blood. Treatment with nitisinone and diet changes may slow the progression of the disease, but will not cure it.

Aug 30, 2024 · Nitisinone works by preventing the body from breaking down an amino acid called tyrosine and by keeping other toxic substances from building up and causing harm to your liver or kidneys. Nitisinone is used to treat a rare genetic condition called hereditary tyrosinemia type 1 …

Oct 29, 2024 · First approved by the FDA in 2002, nitisinone is used to treat hereditary tyrosinemia type 1 (HT-1), an autosomal recessive disorder caused by a deficiency in fumarylacetoacetate hydrolase (FAH). This condition involves the accumulation of toxic intermediates in the tyrosine degradation pathway, resulting in severe liver and kidney damage.

Apr 4, 2022 · Nitisinone is the only medication available to treat hereditary tyrosinemia type 1 (HT-1). It comes as a tablet, capsule, and a suspension form that you take by mouth, typically once or twice daily.

Nitisinone is used to treat a certain inherited disorder (hereditary tyrosinemia type 1, also known as HT-1). HT-1 is usually discovered in infants and needs lifelong treatment.

Indicated for hereditary tyrosinemia type 1 (HT-1) as an adjunct to dietary restriction of tyrosine and phenylalanine. Starting dose: 0.5 mg/kg PO q12hr (morning and evening); titrate dose...

Apr 2, 2024 · Nitisinone is used to treat hereditary tyrosinemia type 1, which is too much tyrosine in the blood. It helps to prevent high levels of tyrosine in the blood. Treatment with nitisinone and diet changes may slow the progression of the disease, but will not cure it.

Nov 18, 2024 · Professional guide for Nitisinone. Includes: pharmacology, pharmacokinetics, contraindications, interactions and adverse reactions.

Jan 25, 2024 · Nityr (nitisinone) tablets are a hydroxyphenyl-pyruvate dioxygenase inhibitor indicated for the treatment of hereditary tyrosinemia type 1 (HT -1) in combination with dietary restriction of tyrosine and phenylalanine. What Are Side Effects of Nityr? Nityr may cause serious side effects including: