Nov 6, 2023 · A new approach that combines CAR T cells with serial mRNA vaccine injections facilitates robust anti-neoplastic activity in patients with genitourinary cancers, which will pave …

Non-viral vector chimeric antigen receptor (CAR)-T cells have garnered increasing attention due to their ability to efficiently eradicate cancer cells while mitigating undesirable side effects.

Dec 1, 2024 · Intriguingly, cell-targeting delivery of messenger RNA (mRNA) with ionizable lipid nanoparticles (mRNA-LNPs) is able to efficiently and precisely engineer T cells and other …

Feb 1, 2024 · Chimeric antigen receptor (CAR) T therapy is a game changer in cancer immunotherapy and beyond. CAR natural killer (NK) cells and CAR macrophages show …

Messenger RNA (mRNA) has been explored as a promising strategy for inducing transient CAR expression in T cells to mitigate the adverse effects associated with viral vectors, but it most …

Oct 21, 2024 · The rationale is that mRNA vaccines can induce a strong initial immune response, while checkpoint inhibitors or CAR T-cells can enhance and sustain the attack on the tumor.

Aug 5, 2024 · Messenger RNA (mRNA)-based transient expression of CAR shows optimal safety profiles and provides promising opportunities to address existing challenges of viral vector …

6 days ago · Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized cancer immunotherapy but continues to face significant challenges that limit its broader application, …

Feb 28, 2025 · Successful therapeutic outcome of CAR-T relies on stable expression of CAR transgene in T cells, this objective is accomplished through the delivery of CAR transgene …

Jan 23, 2025 · In this study, the optimization of CAR-mRNA for T cell applications is investigated, focusing on the impact of mRNA modifications, in vitro transcription protocols, and purification …