Mar 30, 2025 · IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

Apr 7, 2025 · Interleukin 6 plasma levels are associated with progression of coronary plaques. Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.

IL-6 is a soluble mediator with a pleiotropic effect on inflammation, immune response, and hematopoiesis. At first, distinct functions of IL-6 were studied and given distinct names based on their biological activity.

IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely related to chronic inflammatory diseases, autoimmune diseases and cancer) and even in the cytokine storm of corona virus disease 2019 (COVID-19).

The IL-6 gene variant -174 C/G (presence of C-allele) is associated with higher IL-6 gene expression and greater GIT impairment in patients with systemic sclerosis. IL-6 and IL-6R levels increase during the osteogenic differentiation of Bone marrow-derived mesenchymal stem cells.

NF-κB significantly mediates the activation of the IL-6 gene by a variety of IL-6 inducers such as PMA, LPS, TNF-α, poly(IC), and human T lymphotropic virus type I (52, 53). Nonetheless, the function is cell specific including U-937 monocytic cells, HeLa cells, and Jurkat T cells ( 49 , …

Jan 4, 2025 · This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections.

Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the expression of a variety of proteins responsible for acute inflammation, and plays an important role in the proliferation and differentiation of cells in humans.

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.