Feb 2, 2021 · Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice. eLife 10:e62174. Heart failure is a major public health problem, and abnormal iron metabolism is common in patients with heart failure. Although iron is necessary for metabolic homeostasis, it induces a programmed necrosis.

Feb 2, 2021 · DOI: 10.7554/eLife.62174 Abstract Heart failure is a major public health problem, and abnormal iron metabolism is common in patients with heart failure.

Deletion of Ncoa4 in mouse hearts reduced left ventricular chamber size and improved cardiac function along with the attenuation of the upregulation of ferritinophagy-mediated ferritin …

Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated autophagic degradation, known as ferritinophagy. However, the role of ferritinophagy in the stressed heart remains unclear.

May 7, 2024 · Here, we present the cryo-EM structure of the NCOA4-FTH1 interface, resolving 16 amino acids of NCOA4 that are crucial for the interaction. The characterization of mutants, designed to modulate the...

Feb 2, 2021 · Time course of changes in the echocardiographic parameters of left ventricular (LV) fractional shortening (FS), the end-diastolic LV internal dimension (LVIDd) and the end-systolic LV internal … Ablation of Ncoa4 in cardiomyocytes showed defective ferritinophagy.

Feb 2, 2021 · It demonstrates that deletion of the ferritin chaperone NCOA4, which is involved in ferritinophagy, reduces the extent of cardiac remodelling following TAC. It also provides evidence implicating changes in intracellular iron pool as a key driving factor in cardiac remodelling.

Heart failure (HF) refers to a progressive pathological condition when cardiac muscles fail to pump adequate blood supply (cardiac output) to meet the metabolic demand of the body. Among various cellular and molecular mechanisms identified for the onset and progression of HF, autophagy dysregulation is increasingly getting recognized.

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice. eLife, 10, 1-23. Article e62174. https://doi.org/10.7554/eLife.62174.

Oct 14, 2021 · FTH1 has ferroxidase activity and sequestrates labile ferrous iron. Its protein expression is mediated through nuclear receptor coactivator 4 (NCOA4)-mediated autophagic degradation, known as ferritinophagy. However, the role of ferritinophagy in the stressed heart remains unclear.