Eukaryotic translation initiation factor 4 G (eIF4G) is a protein involved in eukaryotic translation initiation and is a component of the eIF4F cap-binding complex. Orthologs of eIF4G have been studied in multiple species, including humans, yeast, and wheat.

Inhibiting expression of eukaryotic translation initiation factor 4G (eIF4G) arrests normal development but extends lifespan when suppressed during adulthood. In addition to reducing overall translation, inhibition alters the stoichiometry of mRNA ...

Mar 28, 2025 · EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma 1) is a Protein Coding gene. Diseases associated with EIF4G1 include Parkinson Disease 18, Autosomal Dominant and Parkinson Disease, Late-Onset. Among its related pathways are Peptide chain elongation and Nervous system development.

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene. [5][6] The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome.

The mRNA is circularized by interactions between eIF4G and the poly-A-binding protein (PABP, purple). eIF4G facilitates recruitment of the 40S ribosomal subunit (light gray, in mammals via binding to eIF3, dark gray) and to the mRNA. eIF4B (orange) interacts with eIF4A and increases its helicase activity. eIF4A then unwinds structures in the 5 ...

May 2, 2024 · The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al. demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response.

Aug 31, 2019 · We discovered that alteration frequency in EIF4G1 is prevalent in human cancers e.g. prostate cancer (~ 25%), ovarian cancer (~ 15%), Head and Neck cancer (~ 13%) and cervical cancer (~ 12.5%). EIF4G1 mRNA and protein levels were high across cancer cell lines from multiple organs.

In mammals, the direct interaction between eukaryotic initiation factor 4G (eIF4G) and eIF3 is thought to act as the molecular bridge between the mRNA cap-binding complex and the 40S subunit. A discrete ∼90 amino acid domain in eIF4G is responsible for binding to eIF3, but the identity of the eIF3 subunit (s) involved is less clear.

Jun 20, 2023 · The eIF4F complex, composed of the cap-binding protein eIF4E, ATP-dependent RNA helicase eIF4A, and scaffolding protein eIF4G, is a pivotal factor in the mRNA translation initiation process. eIF4G1, the major paralogue of the …

Oct 14, 2014 · eIF4G is a scaffold protein around which mRNA, ribosomal subunits and the cap-binding complex assemble in order to accomplish translation. There is evidence for the involvement of eIF4G in maintaining breast and lung cancers .