Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the 5' cap of messenger RNAs (mRNAs) to promote eukaryotic translation initiation.

eIF4F（eukaryotic translation initiation factor 4F，真核起始因子4F）是一种在真核翻译起始中发挥重要功能的复合物。 eIF4F由eIF4A、eIF4E、eIF4G三个起始因子组成。

Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under most circumstances and a primary target for translational control.

eIF4G is a 175.5-kDa scaffolding protein that interacts with eIF3 and the Poly (A)-binding protein (PABP), as well as the other members of the eIF4F complex. eIF4E recognizes and binds to the 5' cap structure of mRNA, while eIF4G binds PABP, which binds the poly (A) tail, potentially circularizing and activating the bound mRNA. eIF4A – a DEAD bo...

May 4, 2023 · In this Perspective article, we discuss how eIF4F-sensitive mRNA translation controls the phenotypes of key non-transformed cells in the TME, with an emphasis on the underlying therapeutic...

Jun 6, 2024 · The eIF4F complex is required to activate mRNAs and recruit them to the small subunit. The core components of the complex—eIF4E, eIF4G, and eIF4A—each fulfill a distinct function during translation.

Oct 2, 2015 · By physical analysis, eIF4F was a heterotrimeric complex of eIF4A, eIF4E, and eIF4G (1). The next studies were to attempt to identify the functions of the various proteins required specifically for natural mRNA translation (eIF4A, eIF4B, and eIF4F). The characteristics of these three proteins were very different.

In eukaryotes, mature mRNAs are exported from the nucleus to the cytosol after splicing. The cap-binding eukaryotic initiation factor 4F (eIF4F), a complex that consists of eIF4E, eIF4G, eIF4A, binds to the mRNAs and activates them.

Formation of eukaryotic initiation factor 4F (eIF4F) is widely considered to be the rate-limiting step in cap-dependent translation initiation. Components of eIF4F are often up-regulated in various cancers, and much work has been done to elucidate ...

In this report, we demonstrate that eIF4GII, but not eIF4GI, is selectively recruited to capped mRNA at the onset of cell differentiation.